Psoriasis is a common, chronic, immune-mediated inflammatory disease that primarily involves the skin
Psoriasis can have different clinical phenotypes; however, plaque-type psoriasis is the most common and is characterized by red scaly skin lesions. Psoriasis is associated with a number of comorbidities, including metabolic diseases, psychologic conditions, and an increased risk for cardiovascular diseases.
It can occur at any age, with a mean age of onset of around 30 years. The global prevalence varies geographically with estimates of up to 4%.
Although the specific cause of psoriasis is unknown, current understanding highlights a key role for IL-17A and IL-17F in driving inflammation.