Ankylosing Spondylitis (AS) or radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory arthritis of the skeleton, with characteristic involvement of the spine and pelvis
The pathology of AS primarily involves inflammation, bone erosion, and new bone formation. Patients can experience back pain, stiffness, and fatigue that can severely compromise daily activities and reduce their quality of life.
The estimated global prevalence of AS is 0.2–0.7%. It primarily affects young people before the age of 30 and can result in progressive disability. Genetic factors are recognized to have a crucial role in the development of axSpA, and it has been linked to presence of HLA-B27.